How to prepare your pre-filled pen
For instructions on how to use the Zegluxen® pre-filled pen, you can watch the video or use the step-by-step guide below

For instructions on how to use the Zegluxen® pre-filled pen, you can watch the video or use the step-by-step guide below
How to use the Zegluxen® pen
Step-by-step guide on how to use the pre-filled pen

Check the name and coloured label of the pen to ensure that it contains liraglutide. Using the wrong medicine could cause you harm. Once checked, pull off the pen cap.

Check that the solution in the pen is clear and colourless by looking through the pen window. You should not use the pen if the solution looks cloudy.

Remove the paper tab from a new disposable needle.

Screw the needle straight and tightly onto your pen.

The needs is covered by two caps. Remove the outer needle cap and place on a clean surface for later.

Carefully remove the inner needle cap and dispose of it.

Check the flow with each new pen prior to your first injection with it. Turn the dose selector until the flow check symbols line up with the pointer.

Hold the pen with the needle pointing up. Then tap the cartridge gently with a finger a few times. This will make any air bubbles collect at the top of the cartridge.

Keep the needle pointed up and press the dose button until the 0mg lines up with the pointer. A drop of medicine should appear at the needle tip. If no drop appears, repeat Check the Flow up to four times. If there is still no drop of medicine, you should change the needle and repeat the steps. Do not use the pen if a drop still does not appear as it indicates the pen is defective and you should use a new one.

Selecting your dose. You should always check that the pointer lines up with the 0mg. Turn the dose selector until your required dose lines up with the pointer (0.6mg, 1.2mg or, 1.8mg). If you have selected the wrong dose, you can change it by simply turning the dose selector backwards until the right dose lines up with the pointer. You should take care not to press the dose button as medicine may come out.

If the dose selector stops before the required dose lines up with the pointer there is not enough medicine left for a full dose. You can either prepare a new full pen for injection or, if advised by your doctor or nurse, split your doses.

If advised by your doctor or nurse, you can split your dose between the current pen and a new pen. Turn the dose selector in either direction until 0.6mg or 1.2mg lines up with the pointer, inject the dose, then prepare a new pen and inject the rest of the dose needed. A calculator may help you to plan the doses.

Insert the needle into the skin, as shown by your doctor or nurse. Be careful not to touch the display or press the dose selector sideways when you inject, as this might interrupt the injection. Press and hold down the dose button until the dose counter shows 0. The 0 must line up with the dose pointer. You may then hear or feel a click.

Keep the dose button pressed down and leave the needle under the skin for at least 6 seconds to make sure you get the full dose.

Pull out the needle. You may see a drop of medicine at the needle tip. This is normal and does not affect your dose.

You should guide the needle tip into the outer needle cap without touching the needle or the outer needle cap.

When the needle is covered, carefully push the outer needle cap completely on. Then unscrew the needle and dispose of it carefully in your sharps bin.

The pen cap can then be replaced. When the pen is empty, you should carefully dispose of it without a needle attached, in accordance with local requirements.
- Zegluxen® (liraglutide) Patient Information Leaflet. Available from https://www.ema.europe.eu/en/documents/product-information/zegluxen-epa: product-information_en.pdf
000697603 | December 2024