How to Administer Dose Titration
As with all GLP-1 receptor agonists, doses need to be administered incrementally and titrated upwards in a step-wise manner, to optimise gastrointestinal tolerability
As with all GLP-1 receptor agonists, doses need to be administered incrementally and titrated upwards in a step-wise manner, to optimise gastrointestinal tolerability
To facilitate gastro-intestinal tolerability of this therapy:1
- Starting dose: 6mg liraglutide should be administered once daily
- After at least 1 week on 0.6 mg once daily (week 2 onwards): the dose should be increased to 1.2 mg liraglutide
- After at least 1 week on 1.2 mg once daily (week 3 onwards): depending on clinical response some patients may benefit from an increase to 1.8mg, although daily doses of 1.8mg are not recommended
Combinations and monitoring:
- When Liraglutide is added to a Sulfonylurea or insulin a dose reduction should be considered to reduce hypoglycaemia risk.
- Combination therapy with sulfonylurea is only valid for adult patients.
- Self-monitoring of blood glucose is not needed in order to adjust the dose of liraglutide, but is needed to adjust the dose of sulfonylurea and insulin, particularly when liraglutide therapy is started and insulin is reduced.
- A stepwise approach to insulin dose reduction is recommended
- Zegluxen® (liraglutide) Summary of Product Characteristics.
000697557 | November 2024